With pharmacodynamic interactions it is not possible to demonstrate a simple systematics as it is in pharmacokinetic interactions instead they require a careful weighing up of which drug groups cause desired and which undesired effects which can in turn either potentiate or weaken each other table 1. Introduction to pharmacokinetics and pharmacodynamics pharmacokinetics is currently defined as the study of the time course of drug absorption distribution metabo lism and excretion clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an individual patient. Interactions may be pharmacodynamic in which interaction is close to the target organ and involves direct antagonism or addition of pharmacological properties alternatively interaction may be pharmacokinetic in which one drug or dietary supplement alters the absorption distribution metabolism or excretion of another drug. Pharmacokinetics pharmacodynamics and drug interactions pharmacokinetics studies the absorption distribution metabolism and excretion of a drug and pharmacodynamics studies the relationship between the drug and its receptors its mechanism of action and therapeutic effect both can play a role in drug drug interactions. Chapter 6 drug interactions study play 2pharmacokinetics interactions 3 pharmacodynamic interactions 4combined toxicity define what a direct chemical or physical drug to drug interaction is drugs combined in the same vile when drugs are physically combined together
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